Diagnosis: Unknown ran for nine episodes during the summer of 1960. Starring Patrick O'Neal as Dr. Daniel Coffee, the show was based on characters created by Lawrence G. Blochman. Dr. Coffee was a crime solving medical examiner who appeared in short stories in the late 1940s and the 1950s. He made his first television appearance on August 22, 1947 in an episode on The Lux Video Theater titled "Diagnosis -- Homicide." Diagnosis: Homicide was also the title of the first Dr. Coffee collection, which won a 1951 Edgar award in the short story category.
"The Case of the Radiant Wine" was the first episode in the summer replacement series and featured Cal Bellini as Coffee's assistant Dr. Motital Mookerji and Chester Morris as Detective Lieutenant Ritter. Also in the cast were such talents as Patricia Barry, Tom Bosley, Larry Hagman, and Phyllis Newman. Rounding out the cast were Millette Alexander, Martin Huston, and Murray Matheson.